Cargando…

Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity

Hepatic de novo lipogenesis is influenced by the branched-chain α-keto acid dehydrogenase (BCKDH) kinase (BCKDK). Here, we aimed to determine whether circulating levels of the immediate substrates of BCKDH, the branched-chain α-keto acids (BCKAs), and hepatic BCKDK expression are associated with the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grenier-Larouche, Thomas, Coulter Kwee, Lydia, Deleye, Yann, Leon-Mimila, Paola, Walejko, Jacquelyn M., McGarrah, Robert W., Marceau, Simon, Trahan, Sylvain, Racine, Christine, Carpentier, André C., Lusis, Aldons J., Ilkayeva, Olga, Vohl, Marie-Claude, Huertas-Vazquez, Adriana, Tchernof, André, Shah, Svati H., Newgard, Christopher B., White, Phillip J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462486/ https://www.ncbi.nlm.nih.gov/pubmed/35797133 http://dx.doi.org/10.1172/jci.insight.159204

Ejemplares similares

Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street
por: White, Phillip J., et al.
Publicado: (2021)

Novel plasma biomarkers improve discrimination of metabolic health independent of weight
por: Ellison, Stephen, et al.
Publicado: (2020)

Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy
por: Truby, Lauren K., et al.
Publicado: (2021)

Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner
por: Chella Krishnan, Karthickeyan, et al.
Publicado: (2020)

Remodeling adipose tissue through in silico modulation of fat storage for the prevention of type 2 diabetes
por: Chénard, Thierry, et al.
Publicado: (2017)

If You’re Ready, I Am Ready (But the Wait Is Harming Us Both) Individual Risks in Institutional Conversions
por: Sharp, Mindy McGarrah
Publicado: (2020)

Methylation and Expression of Immune and Inflammatory Genes in the Offspring of Bariatric Bypass Surgery Patients
por: Guénard, Frédéric, et al.
Publicado: (2013)

Pedagogies of Possibilities: Liberating Moral Imagination by Practicing Pastoral Aesthetics
por: Sharp, Melinda A. McGarrah
Publicado: (2021)

Metabolites and diabetes remission after weight loss
por: Kwee, Lydia Coulter, et al.
Publicado: (2021)

Plasma metabolites associated with functional and clinical outcomes in heart failure with reduced ejection fraction with and without type 2 diabetes
por: Lerman, Joseph B., et al.
Publicado: (2022)

Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure
por: Hunter, Wynn G., et al.
Publicado: (2016)

Comparison of the dipeptidyl peptidase-4 gene methylation levels between severely obese subjects with and without the metabolic syndrome
por: Turcot, Valérie, et al.
Publicado: (2013)

Body mass index is associated with epigenetic age acceleration in the visceral adipose tissue of subjects with severe obesity
por: de Toro-Martín, Juan, et al.
Publicado: (2019)

LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypes
por: Turcot, Valérie, et al.
Publicado: (2012)

Methylation quantitative trait loci within the TOMM20 gene are associated with metabolic syndrome-related lipid alterations in severely obese subjects
por: de Toro-Martín, Juan, et al.
Publicado: (2016)

Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
por: Walejko, Jacquelyn M., et al.
Publicado: (2021)

Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women
por: Houde, Andrée-Anne, et al.
Publicado: (2015)

AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants
por: Ostinelli, Giada, et al.
Publicado: (2021)

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export
por: White, Phillip J., et al.
Publicado: (2016)

Isoproterenol-Induced Cardiac Diastolic Dysfunction in Mice: A Systems Genetics Analysis
por: Wang, Jessica, et al.
Publicado: (2019)

Lipoprotein Subclasses Associated With High‐Risk Coronary Atherosclerotic Plaque: Insights From the PROMISE Clinical Trial
por: McGarrah, Robert W., et al.
Publicado: (2022)

Mitochondrial metabolites predict adverse cardiovascular events in individuals with diabetes
por: Regan, Jessica A., et al.
Publicado: (2023)

Plasma acylcarnitines are associated with pulmonary hypertension
por: Luo, Nancy, et al.
Publicado: (2017)

The genetic architecture of NAFLD among inbred strains of mice
por: Hui, Simon T, et al.
Publicado: (2015)

DUSP1 Gene Polymorphisms Are Associated with Obesity-Related Metabolic Complications among Severely Obese Patients and Impact on Gene Methylation and Expression
por: Guénard, F., et al.
Publicado: (2013)

Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever
por: Yoneshiro, Takeshi, et al.
Publicado: (2021)

2,6-Anhydro-1,3-di-O-benzyl-d-mannitol
por: de Siqueira, Edmilson Clarindo, et al.
Publicado: (2011)

Dimethyl hydrazine-1,2-dicarboxylate–triphenylphosphine oxide (1/1)
por: Doboszewski, Bogdan, et al.
Publicado: (2011)

Complement Receptors C5aR and C5L2 Are Associated with Metabolic Profile, Sex Hormones, and Liver Enzymes in Obese Women Pre- and Postbariatric Surgery
por: Rezvani, Reza, et al.
Publicado: (2014)

Fat Cell Size: Measurement Methods, Pathophysiological Origins, and Relationships With Metabolic Dysregulations
por: Ye, Run Zhou, et al.
Publicado: (2021)

Acute and chronic effect of bariatric surgery on circulating autotaxin levels
por: Bourgeois, Raphaëlle, et al.
Publicado: (2019)

A GWAS follow‐up of obesity‐related SNPs in SYPL2 reveals sex‐specific association with hip circumference
por: de Toro‐Martín, J., et al.
Publicado: (2016)

Branched‐chain α‐keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity
por: Gumus Balikcioglu, Pinar, et al.
Publicado: (2022)

Association of Immune and Metabolic Receptors C5aR and C5L2 with Adiposity in Women
por: Poursharifi, Pegah, et al.
Publicado: (2014)

Temporal Changes in Gene Expression Profile during Mature Adipocyte Dedifferentiation
por: Côté, Julie Anne, et al.
Publicado: (2017)

Role of the TGF‐β pathway in dedifferentiation of human mature adipocytes
por: Côté, Julie Anne, et al.
Publicado: (2017)

Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions
por: Bihlmeyer, Nathan A., et al.
Publicado: (2021)

Coagulation factor with potential for the treatment of heart failure
por: Cao, Yang, et al.
Publicado: (2022)

Downregulation of Complement C3 and C3aR Expression in Subcutaneous Adipose Tissue in Obese Women
por: Gupta, Abhishek, et al.
Publicado: (2014)

Systems-based approaches for investigation of inter-tissue communication
por: Seldin, Marcus M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_12egkvolhemn85ikrvv32c2h1v