Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G

Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a posttranslational regulator of the LDL receptor (LDLR). Recent studies have proposed a role for PCSK9 in regulating immune responses. Using RNA-Seq–based variant discovery, we identified a possible psoriasis-susceptibility locus at 1p32.3, l...

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Detalles Bibliográficos
Autores principales: Merleev, Alexander, Ji-Xu, Antonio, Toussi, Atrin, Tsoi, Lam C., Le, Stephanie T., Luxardi, Guillaume, Xing, Xianying, Wasikowski, Rachael, Liakos, William, Brüggen, Marie-Charlotte, Elder, James T., Adamopoulos, Iannis E., Izumiya, Yoshihiro, Leal, Annie R., Li, Qinyuan, Kuzminykh, Nikolay Y., Kirane, Amanda, Marusina, Alina I., Gudjonsson, Johann E., Maverakis, Emanual
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462487/
https://www.ncbi.nlm.nih.gov/pubmed/35862195
http://dx.doi.org/10.1172/jci.insight.141193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462487/
https://www.ncbi.nlm.nih.gov/pubmed/35862195
http://dx.doi.org/10.1172/jci.insight.141193

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