IL-36 receptor agonist and antagonist imbalance drives neutrophilic inflammation in COPD

Current treatments fail to modify the underlying pathophysiology and disease progression of chronic obstructive pulmonary disease (COPD), necessitating alternative therapies. Here, we show that COPD subjects have increased IL-36γ and decreased IL-36 receptor antagonist (IL-36Ra) in bronchoalveolar a...

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Detalles Bibliográficos
Autores principales: Baker, Jonathan R., Fenwick, Peter S., Koss, Carolin K., Owles, Harriet B., Elkin, Sarah L., Fine, Jay, Thomas, Matthew, El Kasmi, Karim C., Barnes, Peter J., Donnelly, Louise E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462491/
https://www.ncbi.nlm.nih.gov/pubmed/35763349
http://dx.doi.org/10.1172/jci.insight.155581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462491/
https://www.ncbi.nlm.nih.gov/pubmed/35763349
http://dx.doi.org/10.1172/jci.insight.155581

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