Glycocalyx heparan sulfate cleavage promotes endothelial cell angiopoietin-2 expression by impairing shear stress–related AMPK/FoxO1 signaling

Angiopoietin-2 (Ang-2) is a key mediator of vascular disease during sepsis, and elevated plasma levels of Ang-2 are associated with organ injury scores and poor clinical outcomes. We have previously observed that biomarkers of endothelial glycocalyx (EG) damage correlate with plasma Ang-2 levels, su...

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Detalles Bibliográficos
Autores principales: Richter, Robert P., Ashtekar, Amit R., Zheng, Lei, Pretorius, Danielle, Kaushlendra, Tripathi, Sanderson, Ralph D., Gaggar, Amit, Richter, Jillian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462499/
https://www.ncbi.nlm.nih.gov/pubmed/35763350
http://dx.doi.org/10.1172/jci.insight.155010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462499/
https://www.ncbi.nlm.nih.gov/pubmed/35763350
http://dx.doi.org/10.1172/jci.insight.155010

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