Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis

Expression of the tight junction–associated protein junctional adhesion molecule-A (JAM-A) is increased in sepsis, although the significance of this is unknown. Here, we show that septic JAM-A (–/–) mice have increased gut permeability, yet paradoxically have decreased bacteremia and systemic TNF an...

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Detalles Bibliográficos
Autores principales: Klingensmith, Nathan J., Fay, Katherine T., Swift, David A., Bazzano, Julia M.R., Lyons, John D., Chen, Ching-wen, Meng, Mei, Ramonell, Kimberly M., Liang, Zhe, Burd, Eileen M., Parkos, Charles A., Ford, Mandy L., Coopersmith, Craig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462501/
https://www.ncbi.nlm.nih.gov/pubmed/35819838
http://dx.doi.org/10.1172/jci.insight.156255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462501/
https://www.ncbi.nlm.nih.gov/pubmed/35819838
http://dx.doi.org/10.1172/jci.insight.156255

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