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KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis

There is a paucity of information about potential molecular brakes on the activation of fibroblasts that drive tissue fibrosis. The transcription factor Krüppel-like factor 4 (KLF4) is best known as a determinant of cell stemness and a tumor suppressor. We found that its expression was diminished in...

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Detalles Bibliográficos
Autores principales:	Penke, Loka R., Speth, Jennifer M., Huang, Steven K., Fortier, Sean M., Baas, Jared, Peters-Golden, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462506/ https://www.ncbi.nlm.nih.gov/pubmed/35852857 http://dx.doi.org/10.1172/jci.insight.160688

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