Cargando…

Transient RNA structures cause aberrant influenza virus replication and innate immune activation

During infection, the influenza A virus RNA polymerase produces both full-length and aberrant RNA molecules, such as defective viral genomes (DVGs) and mini viral RNAs (mvRNAs). Subsequent innate immune activation involves the binding of host pathogen receptor retinoic acid–inducible gene I (RIG-I)...

Descripción completa

Detalles Bibliográficos
Autores principales:	French, Hollie, Pitré, Emmanuelle, Oade, Michael S., Elshina, Elizaveta, Bisht, Karishma, King, Alannah, Bauer, David L.V., te Velthuis, Aartjan J.W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462681/ https://www.ncbi.nlm.nih.gov/pubmed/36083899 http://dx.doi.org/10.1126/sciadv.abp8655

Ejemplares similares

Cas13-based amplification-free quantification of aberrant RNAs during influenza virus infection
por: Lamb, Caitlin H., et al.
Publicado: (2023)

The influenza virus RNA polymerase as an innate immune agonist and antagonist
por: Elshina, Elizaveta, et al.
Publicado: (2021)

Single-Cell Virus Sequencing of Influenza Infections That Trigger Innate Immunity
por: Russell, Alistair B., et al.
Publicado: (2019)

Evolution of transient RNA structure-RNA polymerase interactions in respiratory RNA virus genomes
por: Rigby, Charlotte, et al.
Publicado: (2023)

A viral ubiquitination switch attenuates innate immunity and triggers nuclear import of virion DNA and infection
por: Bauer, Michael, et al.
Publicado: (2021)

Decoding the Role of Temperature in RNA Virus Infections
por: Bisht, Karishma, et al.
Publicado: (2022)

Comparison of replicating and nonreplicating vaccines against SARS-CoV-2
por: Mudrick, Haley E., et al.
Publicado: (2022)

Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation
por: Bala, Pratyusha, et al.
Publicado: (2023)

An innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins
por: Apte, Shruti, et al.
Publicado: (2023)

An oomycete NLP cytolysin forms transient small pores in lipid membranes
por: Pirc, Katja, et al.
Publicado: (2022)

Molecular architecture of the Chikungunya virus replication complex
por: Tan, Yaw Bia, et al.
Publicado: (2022)

Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization
por: Pagani, Chase A., et al.
Publicado: (2022)

Evolution of transient RNA structure–RNA polymerase interactions in respiratory RNA virus genomes
por: Rigby, Charlotte V, et al.
Publicado: (2023)

Sexually dimorphic activation of innate antitumor immunity prevents adrenocortical carcinoma development
por: Wilmouth, James J., et al.
Publicado: (2022)

Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis
por: Gallus, Marco, et al.
Publicado: (2023)

ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus
por: Manolakou, Theodora, et al.
Publicado: (2022)

Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity
por: Zhang, Chi, et al.
Publicado: (2021)

Multistep mechanism of G-quadruplex resolution during DNA replication
por: Sato, Koichi, et al.
Publicado: (2021)

CHK1 phosphorylates PRIMPOL to promote replication stress tolerance
por: Mehta, Kavi P. M., et al.
Publicado: (2022)

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis
por: Kenney, Adam D., et al.
Publicado: (2022)

Cell surface SARS-CoV-2 nucleocapsid protein modulates innate and adaptive immunity
por: López-Muñoz, Alberto Domingo, et al.
Publicado: (2022)

TENT5 cytoplasmic noncanonical poly(A) polymerases regulate the innate immune response in animals
por: Liudkovska, Vladyslava, et al.
Publicado: (2022)

Marginated aberrant red blood cells induce pathologic vascular stress fluctuations in a computational model of hematologic disorders
por: Cheng, Xiaopo, et al.
Publicado: (2023)

Uncovering the universality of self-replication in protein aggregation and its link to disease
por: Meisl, Georg, et al.
Publicado: (2022)

DNA replication initiation shapes the mutational landscape and expression of the human genome
por: Murat, Pierre, et al.
Publicado: (2022)

The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats
por: Huda, Armela, et al.
Publicado: (2023)

Innate immune cell response to host-parasite interaction in a human intestinal tissue microphysiological system
por: Humayun, Mouhita, et al.
Publicado: (2022)

Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors
por: Grosskopf, Abigail K., et al.
Publicado: (2022)

The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor–resistant ER(+) breast cancer with mitotic aberrations
por: Soria-Bretones, Isabel, et al.
Publicado: (2022)

Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells
por: Phiri, Tracy N., et al.
Publicado: (2023)

Cohesin-dependent chromosome loop extrusion is limited by transcription and stalled replication forks
por: Jeppsson, Kristian, et al.
Publicado: (2022)

An RNA-based system to study hepatitis B virus replication and evaluate antivirals
por: Yu, Yingpu, et al.
Publicado: (2023)

Transient agonism of the sonic hedgehog pathway triggers a permanent transition of skin appendage fate in the chicken embryo
por: Cooper, Rory L., et al.
Publicado: (2023)

Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures
por: Zafferani, Martina, et al.
Publicado: (2021)

More than bad luck: Cancer and aging are linked to replication-driven changes to the epigenome
por: Minteer, Christopher J., et al.
Publicado: (2023)

Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity
por: Fukuda, Shinichi, et al.
Publicado: (2021)

Differential metabolic requirement governed by transcription factor c-Maf dictates innate γδT17 effector functionality in mice and humans
por: Chen, Xu, et al.
Publicado: (2022)

Transient lipid-bound states of spike protein heptad repeats provide insights into SARS-CoV-2 membrane fusion
por: Chiliveri, Sai Chaitanya, et al.
Publicado: (2021)

PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease
por: Duhalde Vega, Maite, et al.
Publicado: (2022)

POLE3 is a repressor of unintegrated HIV-1 DNA required for efficient virus integration and escape from innate immune sensing
por: Thenin-Houssier, Suzie, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5dqf628e648tq8uha7m87lng2k