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Tumor purity adjusted beta values improve biological interpretability of high-dimensional DNA methylation data
A common issue affecting DNA methylation analysis in tumor tissue is the presence of a substantial amount of non-tumor methylation signal derived from the surrounding microenvironment. Although approaches for quantifying and correcting for the infiltration component have been proposed previously, we...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462735/ https://www.ncbi.nlm.nih.gov/pubmed/36084090 http://dx.doi.org/10.1371/journal.pone.0265557 |