Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence

A growing body of theoretical and experimental evidence suggests that intramolecular epistasis is a major determinant of rates and patterns of protein evolution and imposes a substantial constraint on the evolution of novel protein functions. Here, we examine the role of intramolecular epistasis in...

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Detalles Bibliográficos
Autores principales: Mohammadi, Shabnam, Herrera-Álvarez, Santiago, Yang, Lu, Rodríguez-Ordoñez, María del Pilar, Zhang, Karen, Storz, Jay F., Dobler, Susanne, Crawford, Andrew J., Andolfatto, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462791/
https://www.ncbi.nlm.nih.gov/pubmed/35972957
http://dx.doi.org/10.1371/journal.pgen.1010323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462791/
https://www.ncbi.nlm.nih.gov/pubmed/35972957
http://dx.doi.org/10.1371/journal.pgen.1010323

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