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Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence

A growing body of theoretical and experimental evidence suggests that intramolecular epistasis is a major determinant of rates and patterns of protein evolution and imposes a substantial constraint on the evolution of novel protein functions. Here, we examine the role of intramolecular epistasis in...

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Detalles Bibliográficos
Autores principales:	Mohammadi, Shabnam, Herrera-Álvarez, Santiago, Yang, Lu, Rodríguez-Ordoñez, María del Pilar, Zhang, Karen, Storz, Jay F., Dobler, Susanne, Crawford, Andrew J., Andolfatto, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462791/ https://www.ncbi.nlm.nih.gov/pubmed/35972957 http://dx.doi.org/10.1371/journal.pgen.1010323

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