Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase

IMP dehydrogenase(IMPDH) is an essential enzyme that catalyzes the rate‐limiting step in the guanine nucleotide pathway. In eukaryotic cells, GTP binding to the regulatory domain allosterically controls the activity of IMPDH by a mechanism that is fine‐tuned by post‐translational modifications and e...

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Detalles Bibliográficos
Autores principales: Fernández‐Justel, David, Marcos‐Alcalde, Íñigo, Abascal, Federico, Vidaña, Nerea, Gómez‐Puertas, Paulino, Jiménez, Alberto, Revuelta, José L., Buey, Rubén M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Full‐length Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462843/
https://www.ncbi.nlm.nih.gov/pubmed/35481629
http://dx.doi.org/10.1002/pro.4314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462843/
https://www.ncbi.nlm.nih.gov/pubmed/35481629
http://dx.doi.org/10.1002/pro.4314

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