Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor

To clarify the determinants of agonist efficacy in pentameric ligand-gated ion channels, we examined a new compound, aminomethanesulfonic acid (AMS), a molecule intermediate in structure between glycine and taurine. Despite wide availability, to date there are no reports of AMS action on glycine rec...

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Detalles Bibliográficos
Autores principales: Ivica, Josip, Zhu, Hongtao, Lape, Remigijus, Gouaux, Eric, Sivilotti, Lucia G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462852/
https://www.ncbi.nlm.nih.gov/pubmed/35975975
http://dx.doi.org/10.7554/eLife.79148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462852/
https://www.ncbi.nlm.nih.gov/pubmed/35975975
http://dx.doi.org/10.7554/eLife.79148

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