The paradigm of immune escape by SARS-CoV-2 variants and strategies for repositioning subverted mAbs against escaped VOCs

The perpetual emergence of SARS-CoV-2 variants is a serious issue that makes it difficult for the therapeutic antibodies and vaccines to end the COVID-19 pandemic. This article discusses the trend of increasing host fitness and immune escape by the virus and how to devise computational strategies fo...

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Detalles Bibliográficos
Autores principales: Shah, Masaud, Woo, Hyun Goo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462941/
https://www.ncbi.nlm.nih.gov/pubmed/36087577
http://dx.doi.org/10.1016/j.ymthe.2022.08.020
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author Shah, Masaud
Woo, Hyun Goo
author_facet Shah, Masaud
Woo, Hyun Goo
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description The perpetual emergence of SARS-CoV-2 variants is a serious issue that makes it difficult for the therapeutic antibodies and vaccines to end the COVID-19 pandemic. This article discusses the trend of increasing host fitness and immune escape by the virus and how to devise computational strategies for antibodies design and their affinity maturation against emerging SARS-CoV-2 variants.
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spelling pubmed-94629412022-09-10 The paradigm of immune escape by SARS-CoV-2 variants and strategies for repositioning subverted mAbs against escaped VOCs Shah, Masaud Woo, Hyun Goo Mol Ther Opinion The perpetual emergence of SARS-CoV-2 variants is a serious issue that makes it difficult for the therapeutic antibodies and vaccines to end the COVID-19 pandemic. This article discusses the trend of increasing host fitness and immune escape by the virus and how to devise computational strategies for antibodies design and their affinity maturation against emerging SARS-CoV-2 variants. American Society of Gene & Cell Therapy 2022-10-05 2022-09-10 /pmc/articles/PMC9462941/ /pubmed/36087577 http://dx.doi.org/10.1016/j.ymthe.2022.08.020 Text en © 2022 The American Society of Gene and Cell Therapy.
spellingShingle Opinion
Shah, Masaud
Woo, Hyun Goo
The paradigm of immune escape by SARS-CoV-2 variants and strategies for repositioning subverted mAbs against escaped VOCs
title The paradigm of immune escape by SARS-CoV-2 variants and strategies for repositioning subverted mAbs against escaped VOCs
title_full The paradigm of immune escape by SARS-CoV-2 variants and strategies for repositioning subverted mAbs against escaped VOCs
title_fullStr The paradigm of immune escape by SARS-CoV-2 variants and strategies for repositioning subverted mAbs against escaped VOCs
title_full_unstemmed The paradigm of immune escape by SARS-CoV-2 variants and strategies for repositioning subverted mAbs against escaped VOCs
title_short The paradigm of immune escape by SARS-CoV-2 variants and strategies for repositioning subverted mAbs against escaped VOCs
title_sort paradigm of immune escape by sars-cov-2 variants and strategies for repositioning subverted mabs against escaped vocs
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462941/
https://www.ncbi.nlm.nih.gov/pubmed/36087577
http://dx.doi.org/10.1016/j.ymthe.2022.08.020
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