Cargando…

Association of Cytotoxic T-Lymphocyte Antigen-4 Gene Polymorphism with Type 1 Diabetes Mellitus: In silico Analysis of Biological Features of CTLA-4 Protein on Ethiopian Population

BACKGROUND: T1DM is a chronic organ-specific T-cell-mediated autoimmune disease characterized by the selective destruction of β-cells in the islets of Langerhans, resulting in insulin deficiency and hyperglycemia. Genes for cytotoxic T lymphocyte-associated antigen 4 have been hypothesized as possib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ebrahim, Endris, Teklu, Takele, Tajebe, Fitsumbrhan, Wondmagegn, Tadelo, Akelew, Yibeltal, Fiseha, Mesfin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462946/ https://www.ncbi.nlm.nih.gov/pubmed/36091481 http://dx.doi.org/10.2147/DMSO.S375023

Ejemplares similares

Opportunistic Cryptococcal Antigenemia in the HAART Era at HIV Epidemic Settings of Northwest Ethiopia
por: Negash, Markos, et al.
Publicado: (2020)

CD4+ cell count recovery after initiation of antiretroviral therapy in HIV-infected Ethiopian adults
por: Fiseha, Temesgen, et al.
Publicado: (2022)

TNF-α (−308) Gene Polymorphism and Type 2 Diabetes Mellitus in Ethiopian Diabetes Patients
por: Ayelign, Birhanu, et al.
Publicado: (2019)

Immunomodulation of COVID‐19 severity by helminth co‐infection: Implications for COVID‐19 vaccine efficacy
por: Akelew, Yibeltal, et al.
Publicado: (2021)

CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation
por: Lingel, Holger, et al.
Publicado: (2017)

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes
por: Lühder, Fred, et al.
Publicado: (1998)

Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells
por: Doyle, Alden M., et al.
Publicado: (2001)

Common hematological parameters reference intervals for apparently healthy pregnant and non-pregnant women of South Wollo Zone, Amhara Regional State, Northeast Ethiopia
por: Fiseha, Mesfin, et al.
Publicado: (2022)

High Prevalence of Asymptomatic Nasopharyngeal Carriage Rate and Multidrug Resistance Pattern of Streptococcus pneumoniae Among Pre-School Children in North Showa Ethiopia
por: Tilahun, Mihret, et al.
Publicado: (2022)

Rigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor Triggering
por: Yu, Chao, et al.
Publicado: (2011)

Association of Cytotoxic T-Lymphocyte Antigen 4 (CTLA4) and Thyroglobulin (TG) Genetic Variants with Autoimmune Hypothyroidism
por: Patel, Hinal, et al.
Publicado: (2016)

Current Understanding of Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) Signaling in T-Cell Biology and Disease Therapy
por: Kim, Gil-Ran, et al.
Publicado: (2022)

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28
por: Lin, Hua, et al.
Publicado: (1998)

Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes
por: Purohit, Sharad, et al.
Publicado: (2005)

Programmed Cell Death 1 (PD-1) and Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) in Viral Hepatitis
por: Cho, Hyosun, et al.
Publicado: (2017)

Soluble cytotoxic T-lymphocyte–associated antigen 4 (sCTLA-4) as a potential biomarker for diagnosis and evaluation of the prognosis in Glioma
por: Liu, Jiajia, et al.
Publicado: (2021)

Comparison of RPR and ELISA with TPHA for the Diagnosis of Syphilis: Implication for Updating Syphilis Point-of-Care Tests in Ethiopia
por: Negash, Markos, et al.
Publicado: (2018)

T lymphocyte subpopulations and intestinal helminthes profile among tuberculosis patients co-infected with HIV before and after anti tubercular treatment at University of Gondar Hospital, Northwest Ethiopia
por: Wondmagegn, Tadelo, et al.
Publicado: (2020)

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Can Regulate Dendritic Cell–induced Activation and Cytotoxicity of CD8(+) T Cells Independently of CD4(+)T Cell Help
por: McCoy, Kathy D., et al.
Publicado: (1999)

Prevalence of hepatotoxicity among HIV-infected patients in Ethiopia: a systematic review and meta-analysis
por: Mohammed, Ousman, et al.
Publicado: (2022)

Seroprevalence of HIV among pregnant women in Ethiopia: a systematic review and meta-analysis
por: Geremew, Demeke, et al.
Publicado: (2018)

Developing and characterizing a single-domain antibody (nanobody) against human cytotoxic T-lymphocyte-associated protein 4 (hCTLA-4)
por: Sotoudeh, Nazli, et al.
Publicado: (2021)

Combinatorial sympathetic and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockades inhibit the murine melanoma growth by targeting infiltrating T cells
por: Wang, Bin, et al.
Publicado: (2021)

Role of CTLA4 in the Proliferation and Survival of Chronic Lymphocytic Leukemia
por: Mittal, Amit K., et al.
Publicado: (2013)

Atherogenic dyslipidemia and associated risk factors among hypertensive patients of five health facilities in Northeast Ethiopia
por: Mohammed, Ousman, et al.
Publicado: (2023)

Association Between Serum Cytotoxic T Lymphocyte Antigen (CTLA)-4 Level and Disease Progression in Patients With Chronic Hepatitis B
por: Darmadi, Darmadi, et al.
Publicado: (2023)

The synergism of B and T lymphocyte attenuator (BTLA) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4) attenuated acute T-cell mediated rejection and prolonged renal graft survival
por: Zhang, Hengcheng, et al.
Publicado: (2020)

Association of Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Gene Polymorphisms with Autoimmune Thyroid Disease in Children and Adults: Case-Control Study
por: Ting, Wei-Hsin, et al.
Publicado: (2016)

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4(+) T Cells
por: Chen, Wanjun, et al.
Publicado: (1998)

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes
Publicado: (1992)

Helminth species dependent effects on Th1 and Th17 cytokines in active tuberculosis patients and healthy community controls
por: Bewket, Gezahegn, et al.
Publicado: (2022)

B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4)
por: Mandelbrot, Didier A., et al.
Publicado: (1999)

Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Engagement Delivers an Inhibitory Signal through the Membrane-Proximal Region in the Absence of the Tyrosine Motif in the Cytoplasmic Tail
por: Nakaseko, Chiaki, et al.
Publicado: (1999)

Patients with chronic lymphocytic leukaemia (CLL) differ in the pattern of CTLA-4 expression on CLL cells: the possible implications for immunotherapy with CTLA-4 blocking antibody
por: Ciszak, Lidia, et al.
Publicado: (2015)

Prevalence of Intestinal Parasites and Associated Factors among Pulmonary Tuberculosis Suspected Patients Attending University of Gondar Hospital, Gondar, Northwest Ethiopia
por: Tegegne, Yalewayker, et al.
Publicado: (2018)

Expression of immune checkpoint regulators, cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed death-ligand 1 (PD-L1), in female breast carcinomas
por: Kassardjian, Ari, et al.
Publicado: (2018)

Effects Of The COVID-19 Pandemic On A Group Of Patients With Pathogenic Variant of Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA-4) in a Tertiary Center in Florida
por: Timothy, Priyanka, et al.
Publicado: (2022)

CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4(+) T cells
por: Hao, Yuwei, et al.
Publicado: (2023)

A novel CTLA-4 blocking strategy based on nanobody enhances the activity of dendritic cell vaccine-stimulated antitumor cytotoxic T lymphocytes
por: Yang, Wenli, et al.
Publicado: (2023)

Blockade of T Lymphocyte Costimulation with Cytotoxic T Lymphocyte–Associated Antigen 4–Immunoglobulin (Ctla4ig) Reverses the Cellular Pathology of Psoriatic Plaques, Including the Activation of Keratinocytes, Dendritic Cells, and Endothelial Cells
por: Abrams, Judith R., et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_spsi0b1b06a1fsg3gquks77p03