8‐Hydroxy‐1,6‐naphthyridine‐7‐carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease

Human cytomegalovirus (HCMV) replication requires a metal‐dependent endonuclease at the C‐terminus of pUL89 (pUL89‐C) for viral genome packaging and cleavage. We have previously shown that pUL89‐C can be pharmacologically inhibited with designed metal‐chelating compounds. We report herein the synthe...

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Detalles Bibliográficos
Autores principales: Jung, Eunkyung, Majima, Ryuichi, Edwards, Tiffany C., Soto‐Acosta, Ruben, Geraghty, Robert J., Wang, Zhengqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463105/
https://www.ncbi.nlm.nih.gov/pubmed/35879245
http://dx.doi.org/10.1002/cmdc.202200334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463105/
https://www.ncbi.nlm.nih.gov/pubmed/35879245
http://dx.doi.org/10.1002/cmdc.202200334

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