GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance

piRNAs function as guardians of the genome by silencing non-self nucleic acids and transposable elements in animals. Many piRNA factors are enriched in perinuclear germ granules, but whether their localization is required for piRNA biogenesis or function is not known. Here we show that GLH/VASA heli...

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Detalles Bibliográficos
Autores principales: Chen, Wenjun, Brown, Jordan S., He, Tao, Wu, Wei-Sheng, Tu, Shikui, Weng, Zhiping, Zhang, Donglei, Lee, Heng-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463143/
https://www.ncbi.nlm.nih.gov/pubmed/36085149
http://dx.doi.org/10.1038/s41467-022-32880-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463143/
https://www.ncbi.nlm.nih.gov/pubmed/36085149
http://dx.doi.org/10.1038/s41467-022-32880-2

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