Inhibition of the Niemann-Pick C1 protein is a conserved feature of multiple strains of pathogenic mycobacteria

Mycobacterium tuberculosis (Mtb) survives and replicates within host macrophages (MΦ) and subverts multiple antimicrobial defense mechanisms. Previously, we reported that lipids shed by pathogenic mycobacteria inhibit NPC1, the lysosomal membrane protein deficient in the lysosomal storage disorder N...

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Detalles Bibliográficos
Autores principales: Weng, Yuzhe, Shepherd, Dawn, Liu, Yi, Krishnan, Nitya, Robertson, Brian D., Platt, Nick, Larrouy-Maumus, Gerald, Platt, Frances M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463166/
https://www.ncbi.nlm.nih.gov/pubmed/36085278
http://dx.doi.org/10.1038/s41467-022-32553-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463166/
https://www.ncbi.nlm.nih.gov/pubmed/36085278
http://dx.doi.org/10.1038/s41467-022-32553-0

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