Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling

The inability to protect stalled replication forks from nucleolytic degradation drives genome instability and underlies chemosensitivity in BRCA-deficient tumors. An emerging hallmark of BRCA-deficiency is the inability to suppress replication-associated single-stranded DNA (ssDNA) gaps. Here, we re...

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Detalles Bibliográficos
Autores principales: Thakar, Tanay, Dhoonmoon, Ashna, Straka, Joshua, Schleicher, Emily M., Nicolae, Claudia M., Moldovan, George-Lucian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463168/
https://www.ncbi.nlm.nih.gov/pubmed/36085347
http://dx.doi.org/10.1038/s41467-022-33028-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463168/
https://www.ncbi.nlm.nih.gov/pubmed/36085347
http://dx.doi.org/10.1038/s41467-022-33028-y

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