Cargando…

Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling

The inability to protect stalled replication forks from nucleolytic degradation drives genome instability and underlies chemosensitivity in BRCA-deficient tumors. An emerging hallmark of BRCA-deficiency is the inability to suppress replication-associated single-stranded DNA (ssDNA) gaps. Here, we re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thakar, Tanay, Dhoonmoon, Ashna, Straka, Joshua, Schleicher, Emily M., Nicolae, Claudia M., Moldovan, George-Lucian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463168/ https://www.ncbi.nlm.nih.gov/pubmed/36085347 http://dx.doi.org/10.1038/s41467-022-33028-y

Ejemplares similares

The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells
por: Schleicher, Emily M., et al.
Publicado: (2022)

Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells
por: Jackson, Lindsey M, et al.
Publicado: (2021)

Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases
por: Hale, Anastasia, et al.
Publicado: (2023)

The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1
por: Dhoonmoon, Ashna, et al.
Publicado: (2022)

Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly
por: Thakar, Tanay, et al.
Publicado: (2020)

The emerging determinants of replication fork stability
por: Thakar, Tanay, et al.
Publicado: (2021)

WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
por: Datta, Arindam, et al.
Publicado: (2021)

A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks
por: Zhang, Kuo, et al.
Publicado: (2016)

Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR
por: Dhoonmoon, Ashna, et al.
Publicado: (2020)

Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival
por: Khatib, Jude B., et al.
Publicado: (2022)

Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens
por: Clements, Kristen E., et al.
Publicado: (2020)

Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells
por: Clements, Kristen E, et al.
Publicado: (2018)

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors
por: Schleicher, Emily M., et al.
Publicado: (2020)

Human HEL308 Localizes to Damaged Replication Forks and Unwinds Lagging Strand Structures
por: Tafel, Agnieszka A., et al.
Publicado: (2011)

Mono-ADP-ribosylation by PARP10 and PARP14 in genome stability
por: Dhoonmoon, Ashna, et al.
Publicado: (2023)

Histone H3K56 Acetylation, CAF1, and Rtt106 Coordinate Nucleosome Assembly and Stability of Advancing Replication Forks
por: Clemente-Ruiz, Marta, et al.
Publicado: (2011)

Archaeal Hel308 helicase targets replication forks in vivo and in vitro and unwinds lagging strands
por: Guy, Colin P., et al.
Publicado: (2005)

Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates
por: Kurat, Christoph F., et al.
Publicado: (2017)

Role of SUMO modification of human PCNA at stalled replication fork
por: Gali, Himabindu, et al.
Publicado: (2012)

TRAIP regulates replication fork recovery and progression via PCNA
por: Feng, Wanjuan, et al.
Publicado: (2016)

CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands
por: Rouillon, Clément, et al.
Publicado: (2023)

New histone supply regulates replication fork speed and PCNA unloading
por: Mejlvang, Jakob, et al.
Publicado: (2014)

Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression
por: Chauhan, Ravi, et al.
Publicado: (2023)

Cycling of the E. coli lagging strand polymerase is triggered exclusively by the availability of a new primer at the replication fork
por: Yuan, Quan, et al.
Publicado: (2014)

Nucleosome assembly and genome integrity: The fork is the link
por: Prado, Félix, et al.
Publicado: (2012)

Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators
por: Wessel, Sarah R., et al.
Publicado: (2019)

A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation
por: Arakawa, Hiroshi, et al.
Publicado: (2006)

Human CAF-1-dependent nucleosome assembly in a defined system
por: Kadyrova, Lyudmila Y, et al.
Publicado: (2013)

Regulation of Replication Fork Advance and Stability by Nucleosome Assembly
por: Prado, Felix, et al.
Publicado: (2017)

The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA
por: Chilkova, Olga, et al.
Publicado: (2007)

Mechanisms of DNA Damage Tolerance: Post-Translational Regulation of PCNA
por: Leung, Wendy, et al.
Publicado: (2018)

The PCNA unloader Elg1 promotes recombination at collapsed replication forks in fission yeast
por: Tamang, Sanjeeta, et al.
Publicado: (2019)

Replication fork reversal triggers fork degradation in BRCA2-defective cells
por: Mijic, Sofija, et al.
Publicado: (2017)

Rtt109 promotes nucleosome replacement ahead of the replication fork
por: Jonas, Felix, et al.
Publicado: (2022)

Ubiquitin/SUMO modification of PCNA promotes replication fork progression in Xenopus laevis egg extracts
por: Leach, Craig A., et al.
Publicado: (2005)

RAD54L regulates replication fork progression and nascent strand degradation in BRCA1/2-deficient cells
por: Uhrig, Mollie E., et al.
Publicado: (2023)

The in vivo measurement of replication fork velocity and pausing by lag-time analysis
por: Huang, Dean, et al.
Publicado: (2023)

The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1
por: Mattiroli, Francesca, et al.
Publicado: (2017)

The fork protection complex recruits FACT to reorganize nucleosomes during replication
por: Safaric, Barbara, et al.
Publicado: (2022)

Single strand transposition at the host replication fork
por: Lavatine, Laure, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_884h3cmcba5rpgftr94ch3qeb6