Anti-CD38 antibody therapy for patients with relapsed/refractory multiple myeloma: differential mechanisms of action and recent clinical trial outcomes

CD38 is a transmembrane glycoprotein that functions both as a receptor and an ectoenzyme, playing key roles in the regulation of calcium signaling and migration of immune cells to tumor microenvironments. High expression on multiple myeloma (MM) cells and limited expression on normal cells makes CD3...

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Detalles Bibliográficos
Autores principales: Leleu, Xavier, Martin, Thomas, Weisel, Katja, Schjesvold, Fredrik, Iida, Shinsuke, Malavasi, Fabio, Manier, Salomon, Chang-Ki Min, Ocio, Enrique M., Pawlyn, Charlotte, Perrot, Aurore, Quach, Hang, Richter, Joshua, Spicka, Ivan, Yong, Kwee, Richardson, Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463192/
https://www.ncbi.nlm.nih.gov/pubmed/35943588
http://dx.doi.org/10.1007/s00277-022-04917-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463192/
https://www.ncbi.nlm.nih.gov/pubmed/35943588
http://dx.doi.org/10.1007/s00277-022-04917-5

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