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Silencing Itch in human peripheral blood monocytes promotes their differentiation into osteoclasts
INTRODUCTION: Two clinical case reports of humans with mutations in Itch reported distinct morphological defects such as stunted growth, macrocephaly, and dysmorphic features indicating a role for Itch in bone remodelling. Studies in mice have found that the encoded E3 ubiquitin ligase acts as a neg...
| Autores principales: | , |
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| 格式: | Online Artículo Texto |
| 語言: | English |
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Springer Netherlands
2022
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| 主題: | |
| 在線閱讀: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463264/ https://www.ncbi.nlm.nih.gov/pubmed/35793050 http://dx.doi.org/10.1007/s11033-022-07726-1 |