Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations

Antibiotic-resistant pathogens are a major public health threat. A deeper understanding of how an antibiotic’s mechanism of action influences the emergence of resistance would aid in the design of new drugs and help to preserve the effectiveness of existing ones. To this end, we developed a model th...

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Detalles Bibliográficos
Autores principales: Hemez, Colin, Clarelli, Fabrizio, Palmer, Adam C., Bleis, Christina, Abel, Sören, Chindelevitch, Leonid, Cohen, Theodore, Abel zur Wiesch, Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463365/
https://www.ncbi.nlm.nih.gov/pubmed/36147681
http://dx.doi.org/10.1016/j.csbj.2022.08.030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463365/
https://www.ncbi.nlm.nih.gov/pubmed/36147681
http://dx.doi.org/10.1016/j.csbj.2022.08.030

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