Cargando…

Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis

Gasdermin D (GSDMD) and gasdermin E (GSDME) perpetuate inflammation by mediating the release of cytokines such as interleukin-1β (IL-1β) and IL-18. However, not only are the actions of GSDMD in colitis still controversial, but its interplay with GSDME in the pathogenesis of this disease has not been...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Jianqiu, Sun, Kai, Wang, Chun, Abu-Amer, Yousef, Mbalaviele, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463374/
https://www.ncbi.nlm.nih.gov/pubmed/36097634
http://dx.doi.org/10.1016/j.jtauto.2022.100162