Design, synthesis, and evaluation of fluoroquinolone derivatives as microRNA-21 small-molecule inhibitors

MicroRNA-21 (miRNA-21) is highly expressed in various tumors. Small-molecule inhibition of miRNA-21 is considered to be an attractive novel cancer therapeutic strategy. In this study, fluoroquinolone derivatives A1–A43 were synthesized and used as miRNA-21 inhibitors. Compound A36 showed the most po...

Descripción completa

Detalles Bibliográficos
Autores principales: Hei, Yuan-Yuan, Wang, Si, Xi, Xiao-Xiao, Wang, Hai-Peng, Guo, Yuanxu, Xin, Minhang, Jiang, Congshan, Lu, Shemin, Zhang, San-Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463491/
https://www.ncbi.nlm.nih.gov/pubmed/36105166
http://dx.doi.org/10.1016/j.jpha.2021.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463491/
https://www.ncbi.nlm.nih.gov/pubmed/36105166
http://dx.doi.org/10.1016/j.jpha.2021.12.008

Ejemplares similares