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Design, synthesis, and evaluation of fluoroquinolone derivatives as microRNA-21 small-molecule inhibitors
MicroRNA-21 (miRNA-21) is highly expressed in various tumors. Small-molecule inhibition of miRNA-21 is considered to be an attractive novel cancer therapeutic strategy. In this study, fluoroquinolone derivatives A1–A43 were synthesized and used as miRNA-21 inhibitors. Compound A36 showed the most po...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Xi'an Jiaotong University
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463491/ https://www.ncbi.nlm.nih.gov/pubmed/36105166 http://dx.doi.org/10.1016/j.jpha.2021.12.008 |