Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments

DNA synthesis of the leading and lagging strands works independently and cells tolerate single-stranded DNA generated during strand uncoupling if it is protected by RPA molecules. Natural alkaloid emetine is used as a specific inhibitor of lagging strand synthesis, uncoupling leading and lagging str...

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Detalles Bibliográficos
Autores principales: Lukac, David, Machacova, Zuzana, Moudry, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463495/
https://www.ncbi.nlm.nih.gov/pubmed/36260751
http://dx.doi.org/10.26508/lsa.202201560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463495/
https://www.ncbi.nlm.nih.gov/pubmed/36260751
http://dx.doi.org/10.26508/lsa.202201560

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