Cargando…

Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments

DNA synthesis of the leading and lagging strands works independently and cells tolerate single-stranded DNA generated during strand uncoupling if it is protected by RPA molecules. Natural alkaloid emetine is used as a specific inhibitor of lagging strand synthesis, uncoupling leading and lagging str...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lukac, David, Machacova, Zuzana, Moudry, Pavel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463495/ https://www.ncbi.nlm.nih.gov/pubmed/36260751 http://dx.doi.org/10.26508/lsa.202201560

Ejemplares similares

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication
por: Hanzlikova, Hana, et al.
Publicado: (2018)

High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication
por: Williams, Jessica S., et al.
Publicado: (2021)

Alternative Okazaki Fragment Ligation Pathway by DNA Ligase III
por: Arakawa, Hiroshi, et al.
Publicado: (2015)

The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication
por: Levikova, Maryna, et al.
Publicado: (2015)

Processing of eukaryotic Okazaki fragments by redundant nucleases can be uncoupled from ongoing DNA replication in vivo
por: Kahli, Malik, et al.
Publicado: (2019)

Days weaving the lagging strand synthesis of DNA — A personal recollection of the discovery of Okazaki fragments and studies on discontinuous replication mechanism —
por: OKAZAKI, Tsuneko
Publicado: (2017)

Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly
por: Thakar, Tanay, et al.
Publicado: (2020)

Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing
por: Becker, Jordan R., et al.
Publicado: (2015)

Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression
por: Nguyen, Hai Dang, et al.
Publicado: (2013)

Replication-Coupled PCNA Unloading by the Elg1 Complex Occurs Genome-wide and Requires Okazaki Fragment Ligation
por: Kubota, Takashi, et al.
Publicado: (2015)

Resolving individual steps of Okazaki fragment maturation at msec time-scale
por: Stodola, Joseph L., et al.
Publicado: (2016)

Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing
por: Blair, Kerry, et al.
Publicado: (2022)

Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics
por: Raducanu, Vlad-Stefan, et al.
Publicado: (2022)

The Roles of Family B and D DNA Polymerases in Thermococcus Species 9°N Okazaki Fragment Maturation
por: Greenough, Lucia, et al.
Publicado: (2015)

Missed cleavage opportunities by FEN1 lead to Okazaki fragment maturation via the long-flap pathway
por: Zaher, Manal S, et al.
Publicado: (2018)

TbPIF5 Is a Trypanosoma brucei Mitochondrial DNA Helicase Involved in Processing of Minicircle Okazaki Fragments
por: Liu, Beiyu, et al.
Publicado: (2009)

Emetine
por: Servoss, George L.
Publicado: (1909)

Coordination of multiple enzyme activities by a single PCNA in archaeal Okazaki fragment maturation
por: Beattie, Thomas R, et al.
Publicado: (2012)

Author Correction: Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing
por: Blair, Kerry, et al.
Publicado: (2023)

PCNA acts as a stationary loading platform for transiently interacting Okazaki fragment maturation proteins
por: Sporbert, Anje, et al.
Publicado: (2005)

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro
por: Choy, Ka-Tim, et al.
Publicado: (2020)

Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1
por: Gloor, Jason W., et al.
Publicado: (2012)

Emetine Administration
por: Dawson, A.
Publicado: (1927)

The Therapeutics of Emetine
por: Chopra, R. N., et al.
Publicado: (1922)

The Action of Emetine
Publicado: (1926)

Emetine in Cholera
por: Rogers, Leonard
Publicado: (1915)

The Abuse of Emetine
por: McRobert, G. R.
Publicado: (1925)

The Toxicity of Emetine
Publicado: (1943)

Ipecacuanha and Emetine
Publicado: (1893)

Emetine and Dysentery
por: Betts, A. J. V.
Publicado: (1914)

Emetine in Haemoptysis
Publicado: (1914)

Involvement of Vts1, a structure-specific RNA-binding protein, in Okazaki fragment processing in yeast
por: Lee, Chul-Hwan, et al.
Publicado: (2010)

SV40 T antigen helicase domain regions responsible for oligomerisation regulate Okazaki fragment synthesis initiation
por: Onwubiko, Nichodemus O., et al.
Publicado: (2022)

Natural Plant Alkaloid (Emetine) Inhibits HIV-1 Replication by Interfering with Reverse Transcriptase Activity
por: Valadão, Ana Luiza Chaves, et al.
Publicado: (2015)

In vivo and in vitro studies of Mgs1 suggest a link between genome instability and Okazaki fragment processing
por: Kim, Jeong-Hoon, et al.
Publicado: (2005)

WRN helicase unwinds Okazaki fragment-like hybrids in a reaction stimulated by the human DHX9 helicase
por: Chakraborty, Prasun, et al.
Publicado: (2010)

Emetine and Liver Abscess
por: Mallannah, S.
Publicado: (1913)

Emetine during Pregnancy
por: Deb, T. N.
Publicado: (1915)

Emetine in the Dysentery of Children
Publicado: (1914)

Emetine Injections in Sprue
por: Dholakia, Keshavlal J.
Publicado: (1919)

Cannot write session to /tmp/vufind_sessions/sess_3bccgl896dc41ht82j2qi7h87i