In silico studies of M(pro) and PL(pro) from SARS-CoV-2 and a new class of cephalosporin drugs containing 1,2,4-thiadiazole

The SARS-CoV-2 proteases M(pro) and PL(pro) are important targets for the development of antivirals against COVID-19. The functional group 1,2,4-thiadiazole has been indicated to inhibit cysteinyl proteases, such as papain and cathepsins. Of note, the 1,2,4-thiadiazole moiety is found in a new class...

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Detalles Bibliográficos
Autores principales: Delgado, Cássia Pereira, Rocha, João Batista Teixeira, Orian, Laura, Bortoli, Marco, Nogara, Pablo Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463509/
https://www.ncbi.nlm.nih.gov/pubmed/36106095
http://dx.doi.org/10.1007/s11224-022-02036-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463509/
https://www.ncbi.nlm.nih.gov/pubmed/36106095
http://dx.doi.org/10.1007/s11224-022-02036-5

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