Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes

Strains of Clostridium perfringens produce a two-domain enterotoxin (CpE) that afflicts humans and domesticated animals, causing prevalent gastrointestinal illnesses. CpE’s C-terminal domain (cCpE) binds cell surface receptors, followed by a restructuring of its N-terminal domain to form a membrane-...

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Detalles Bibliográficos
Autores principales: Orlando, Benjamin J., Dominik, Pawel K., Roy, Sourav, Ogbu, Chinemerem P., Erramilli, Satchal K., Kossiakoff, Anthony A., Vecchio, Alex J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463536/
https://www.ncbi.nlm.nih.gov/pubmed/35952760
http://dx.doi.org/10.1016/j.jbc.2022.102357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463536/
https://www.ncbi.nlm.nih.gov/pubmed/35952760
http://dx.doi.org/10.1016/j.jbc.2022.102357

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