Subgenomic particles in rAAV vectors result from DNA lesion/break and non-homologous end joining of vector genomes

Recombinant adeno-associated virus (rAAV) vectors have been developed for therapeutic treatment of genetic diseases. Current rAAV vectors administered to affected individuals often contain vector DNA-related contaminants. Here we present a thorough molecular analysis of the configuration of non-stan...

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Detalles Bibliográficos
Autores principales: Zhang, Junping, Guo, Ping, Yu, Xiangping, Frabutt, Dylan A., Lam, Anh K., Mulcrone, Patrick L., Chrzanowski, Matthew, Firrman, Jenni, Pouchnik, Derek, Sang, Nianli, Diao, Yong, Herzog, Roland W., Xiao, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463555/
https://www.ncbi.nlm.nih.gov/pubmed/36159586
http://dx.doi.org/10.1016/j.omtn.2022.08.027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463555/
https://www.ncbi.nlm.nih.gov/pubmed/36159586
http://dx.doi.org/10.1016/j.omtn.2022.08.027

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