The structure and characterization of human cytochrome P450 8B1 supports future drug design for nonalcoholic fatty liver disease and diabetes

Human cytochrome P450 8B1 (CYP8B1) is involved in conversion of cholesterol to bile acids. It hydroxylates the steroid ring at C12 to ultimately produce the bile acid cholic acid. Studies implicated this enzyme as a good drug target for nonalcoholic fatty liver disease and type 2 diabetes, but there...

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Detalles Bibliográficos
Autores principales: Liu, Jinghan, Carlson, Heather A., Scott, Emily E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463588/
https://www.ncbi.nlm.nih.gov/pubmed/35944583
http://dx.doi.org/10.1016/j.jbc.2022.102344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463588/
https://www.ncbi.nlm.nih.gov/pubmed/35944583
http://dx.doi.org/10.1016/j.jbc.2022.102344

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