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Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells
BACKGROUND: Lysophosphatidic acid receptor 3 (LPAR3) is coupled to Gα(i/o) and Gα(11/q) signaling. Previously, we reported that LPAR3 is highly methylated in carcinogen-induced transformed cells. Here, we demonstrate that LPAR3 exhibits malignant transforming activities, despite being downregulated...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463806/ https://www.ncbi.nlm.nih.gov/pubmed/36088312 http://dx.doi.org/10.1186/s12885-022-10053-0 |