Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein

GPR17 is a class A orphan G protein‐coupled receptor (GPCR) expressed in neurons and oligodendrocyte progenitors of the central nervous system (CNS). The signalling of GPR17 occurs through the heterotrimeric Gi, but its activation mechanism is unclear. Here, we employed cryo‐electron microscopy (cry...

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Detalles Bibliográficos
Autores principales: Ye, Fang, Wong, Thian‐Sze, Chen, Geng, Zhang, Zhiyi, Zhang, Binghao, Gan, Shiyi, Gao, Wei, Li, Jiancheng, Wu, Zhangsong, Pan, Xin, Du, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464062/
https://www.ncbi.nlm.nih.gov/pubmed/36105372
http://dx.doi.org/10.1002/mco2.159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464062/
https://www.ncbi.nlm.nih.gov/pubmed/36105372
http://dx.doi.org/10.1002/mco2.159

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