Cargando…

Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein

GPR17 is a class A orphan G protein‐coupled receptor (GPCR) expressed in neurons and oligodendrocyte progenitors of the central nervous system (CNS). The signalling of GPR17 occurs through the heterotrimeric Gi, but its activation mechanism is unclear. Here, we employed cryo‐electron microscopy (cry...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Fang, Wong, Thian‐Sze, Chen, Geng, Zhang, Zhiyi, Zhang, Binghao, Gan, Shiyi, Gao, Wei, Li, Jiancheng, Wu, Zhangsong, Pan, Xin, Du, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464062/ https://www.ncbi.nlm.nih.gov/pubmed/36105372 http://dx.doi.org/10.1002/mco2.159

Ejemplares similares

Cryo‐EM structure of orphan G protein‐coupled receptor GPR21
por: Wong, Thian‐Sze, et al.
Publicado: (2023)

Fusion protein strategies for cryo-EM study of G protein-coupled receptors
por: Zhang, Kaihua, et al.
Publicado: (2022)

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
por: Wong, Thian-Sze, et al.
Publicado: (2023)

Synthesis and Ability of New Ligands for G Protein-Coupled Receptors 17 (GPR17)
por: Zhuo, Tongyou, et al.
Publicado: (2017)

Cryo-EM structures of human bradykinin receptor-G(q) proteins complexes
por: Shen, Jinkang, et al.
Publicado: (2022)

Cryo-EM structure of the activated GLP-1 receptor in complex with G protein
por: Zhang, Yan, et al.
Publicado: (2017)

Cryo-EM structure of the adenosine A(2A) receptor coupled to an engineered heterotrimeric G protein
por: García-Nafría, Javier, et al.
Publicado: (2018)

Stachel-mediated activation of adhesion G protein-coupled receptors: insights from cryo-EM studies
por: Liebscher, Ines, et al.
Publicado: (2022)

Cryo-EM structures of orphan GPR21 signaling complexes
por: Lin, Xi, et al.
Publicado: (2023)

Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein
por: Chen, Geng, et al.
Publicado: (2020)

Phase-plate cryo-EM structure of a class B GPCR-G protein complex
por: Liang, Yi-Lynn, et al.
Publicado: (2017)

Signaling at the endosome: cryo‐EM structure of a GPCR–G protein–beta‐arrestin megacomplex
por: Nguyen, Anthony H., et al.
Publicado: (2021)

The oligodendrocyte-specific G-protein coupled receptor GPR17 is a cell-intrinsic timer of myelination
por: Chen, Ying, et al.
Publicado: (2009)

G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Differentiation in Response to Lysolecithin-Induced Demyelination
por: Lu, Changqing, et al.
Publicado: (2018)

Knockdown of G protein-coupled receptor-17 (GPR17) facilitates the regeneration and repair of myelin sheath post-periventricular leukomalacia (PVL)
por: He, Liufang, et al.
Publicado: (2021)

Detergents and alternatives in cryo-EM studies of membrane proteins: Detergents and alternatives in cryo-EM studies of membrane proteins
por: Li, Shuo
Publicado: (2022)

Pharmacology and function of the orphan GPR139 G protein‐coupled receptor
por: Vedel, Line, et al.
Publicado: (2019)

Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies
por: Zhang, Hanzhi, et al.
Publicado: (2021)

Functional Heterodimerization between the G Protein-Coupled Receptor GPR17 and the Chemokine Receptors 2 and 4: New Evidence
por: Daniele, Simona, et al.
Publicado: (2022)

Identification of Metabolic Pathways Influenced by the G-Protein Coupled Receptors GprB and GprD in Aspergillus nidulans
por: de Souza, Wagner R., et al.
Publicado: (2013)

Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system
por: SARKAR, Sonjoy, et al.
Publicado: (2020)

Allosteric coupling between G‐protein binding and extracellular ligand binding sites in GPR52 revealed by (19)F‐NMR and cryo‐electron microscopy
por: Fan, Yanliu, et al.
Publicado: (2023)

Cryo-EM grid optimization for membrane proteins
por: Kampjut, Domen, et al.
Publicado: (2021)

Forty years in cryoEM of membrane proteins
por: Kühlbrandt, Werner
Publicado: (2022)

G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health
por: Kim, Mi-Jin, et al.
Publicado: (2015)

The G protein–coupled receptor GPR31 promotes membrane association of KRAS
por: Fehrenbacher, Nicole, et al.
Publicado: (2017)

Structural basis for adhesion G protein-coupled receptor Gpr126 function
por: Leon, Katherine, et al.
Publicado: (2020)

G Protein-Coupled Receptor GPR35 Suppresses Lipid Accumulation in Hepatocytes
por: Lin, Li-Chiung, et al.
Publicado: (2021)

Therapeutic validation of an orphan G protein‐coupled receptor: The case of GPR84
por: Marsango, Sara, et al.
Publicado: (2020)

Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process
por: Maudsley, Stuart, et al.
Publicado: (2022)

Cryo-EM structure of the human histamine H(1) receptor/G(q) complex
por: Xia, Ruixue, et al.
Publicado: (2021)

Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy
por: Duan, Jia, et al.
Publicado: (2020)

The trafficking of GPR55 is regulated by the G protein-coupled receptor-associated sorting protein 1
por: Kargl, Julia, et al.
Publicado: (2010)

Direct IgG epitope mapping on bacterial AB toxins by cryo-EM
por: Nguyen, Tri, et al.
Publicado: (2021)

Time-resolved cryo-EM visualizes ribosomal translocation with EF-G and GTP
por: Carbone, Christine E., et al.
Publicado: (2021)

Cryo-EM structure of the endothelin-1-ET(B)-G(i) complex
por: Sano, Fumiya K, et al.
Publicado: (2023)

Cryo-EM structure of the serotonin 5-HT(1B) receptor coupled to heterotrimeric G(o)
por: García-Nafría, Javier, et al.
Publicado: (2018)

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G(s)
por: Xu, Lu, et al.
Publicado: (2021)

Assessment of protein–protein interfaces in cryo-EM derived assemblies
por: Malhotra, Sony, et al.
Publicado: (2021)

In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM
por: Huang, Cheng-Yu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rtnf7v4jejkt41al4r8tjau85s