Deciphering the pathway-specific regulatory network for production of ten-membered enediyne Tiancimycins in Streptomyces sp. CB03234-S

BACKGROUND: The anthraquinone-fused 10-membered enediynes (AFEs), represented by tiancimycins (TNMs), possess a unique structural feature and promising potentials as payloads of antitumor antibody–drug conjugates. Despite many efforts, the insufficient yields remain a practical challenge for develop...

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Detalles Bibliográficos
Autores principales: Zhu, Manxiang, Zhang, Fan, Gan, Ting, Lin, Jing, Duan, Yanwen, Zhu, Xiangcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464397/
https://www.ncbi.nlm.nih.gov/pubmed/36088456
http://dx.doi.org/10.1186/s12934-022-01916-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464397/
https://www.ncbi.nlm.nih.gov/pubmed/36088456
http://dx.doi.org/10.1186/s12934-022-01916-z

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