Exosite binding modulates the specificity of the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease

The C5a peptidase from Streptococcus pyogenes (ScpA) is a highly specific enzyme with potential therapeutic value. ScpA is a good model for studying determinants of specificity in the multidomain immunomodulatory enzymes (IMEs), which comprise a large family of bacterial surface proteases. The surfa...

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Detalles Bibliográficos
Autores principales: Jain, Monica, Teçza, Malgorzata, Kagawa, Todd F., Cooney, Jakki C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464890/
https://www.ncbi.nlm.nih.gov/pubmed/36147677
http://dx.doi.org/10.1016/j.csbj.2022.08.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464890/
https://www.ncbi.nlm.nih.gov/pubmed/36147677
http://dx.doi.org/10.1016/j.csbj.2022.08.018

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