Partial prevention of glucocorticoid-induced osteocyte deterioration in young male mice with osteocrin gene therapy

Glucocorticoid excess suppresses osteocyte remodeling of surrounding bone minerals, causes apoptosis of osteoblasts and osteocytes, and disrupts bone remodeling, eventually, leading to glucocorticoid-induced osteoporosis and bone fragility. Preventing apoptosis and preserving osteocyte morphology co...

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Detalles Bibliográficos
Autores principales: Mazur, Courtney M., Castro Andrade, Christian D., Tokavanich, Nicha, Sato, Tadatoshi, Bruce, Michael, Brooks, Daniel J., Bouxsein, Mary L., Wang, Jialiang S., Wein, Marc N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464962/
https://www.ncbi.nlm.nih.gov/pubmed/36105586
http://dx.doi.org/10.1016/j.isci.2022.105019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464962/
https://www.ncbi.nlm.nih.gov/pubmed/36105586
http://dx.doi.org/10.1016/j.isci.2022.105019

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