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Resolving primary pathomechanisms driving idiopathic-like spinal curvature using a new katnb1 scoliosis model

Idiopathic scoliosis (IS) refers to abnormal spinal curvatures that occur in the absence of vertebral or neuromuscular defects. IS accounts for 80% of human spinal deformity, afflicts ∼3% of children worldwide, yet pathogenic mechanisms are poorly understood. A key role for cerebrospinal fluid (CSF)...

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Detalles Bibliográficos
Autores principales: Meyer-Miner, Anne, Van Gennip, Jenica L.M., Henke, Katrin, Harris, Matthew P., Ciruna, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464966/
https://www.ncbi.nlm.nih.gov/pubmed/36105588
http://dx.doi.org/10.1016/j.isci.2022.105028