Improved pharmacokinetics of tenofovir ester prodrugs strengthened the inhibition of HBV replication and the rebalance of hepatocellular metabolism in preclinical models

Tenofovir (TFV) ester prodrugs, a class of nucleotide analogs (NAs), are the first-line clinical anti-hepatitis B virus (HBV) drugs with potent antiviral efficacy, low resistance rate and high safety. In this work, three marketed TFV ester drugs, tenofovir disoproxil fumarate (TDF), tenofovir alafen...

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Detalles Bibliográficos
Autores principales: Hong, Xiaodan, Cai, Zuhuan, Zhou, Fang, Jin, Xiaoliang, Wang, Guangji, Ouyang, Bingchen, Zhang, Jingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465247/
https://www.ncbi.nlm.nih.gov/pubmed/36105197
http://dx.doi.org/10.3389/fphar.2022.932934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465247/
https://www.ncbi.nlm.nih.gov/pubmed/36105197
http://dx.doi.org/10.3389/fphar.2022.932934

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