Cargando…

Improved pharmacokinetics of tenofovir ester prodrugs strengthened the inhibition of HBV replication and the rebalance of hepatocellular metabolism in preclinical models

Tenofovir (TFV) ester prodrugs, a class of nucleotide analogs (NAs), are the first-line clinical anti-hepatitis B virus (HBV) drugs with potent antiviral efficacy, low resistance rate and high safety. In this work, three marketed TFV ester drugs, tenofovir disoproxil fumarate (TDF), tenofovir alafen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hong, Xiaodan, Cai, Zuhuan, Zhou, Fang, Jin, Xiaoliang, Wang, Guangji, Ouyang, Bingchen, Zhang, Jingwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465247/ https://www.ncbi.nlm.nih.gov/pubmed/36105197 http://dx.doi.org/10.3389/fphar.2022.932934

Ejemplares similares

Development of a Transdermal Delivery System for Tenofovir Alafenamide, a Prodrug of Tenofovir with Potent Antiviral Activity Against HIV and HBV
por: Puri, Ashana, et al.
Publicado: (2019)

Straightening the Eyes Doesn't Rebalance the Brain
por: Zhou, Jiawei, et al.
Publicado: (2017)

Preclinical Pharmacokinetics of C118P, a Novel Prodrug of Microtubules Inhibitor and Its Metabolite C118 in Mice, Rats, and Dogs
por: Zhang, Cang, et al.
Publicado: (2018)

Lysosomal Diseases and Neuropsychiatry: Opportunities to Rebalance the Mind
por: Cox, Timothy M.
Publicado: (2020)

Esters of valerenic acid as potential prodrugs
por: Hintersteiner, Juliane, et al.
Publicado: (2014)

Effect of Pregnancy and Concomitant Antiretrovirals on the Pharmacokinetics of Tenofovir in Women With HIV Receiving Tenofovir Disoproxil Fumarate‐Based Antiretroviral Therapy Versus Women With HBV Receiving Tenofovir Disoproxil Fumarate Monotherapy
por: Bukkems, Vera E., et al.
Publicado: (2020)

HBV genotypes and response to tenofovir disoproxil fumarate in HIV/HBV-coinfected persons
por: Bihl, Florian, et al.
Publicado: (2015)

Population pharmacokinetics of tenofovir and tenofovir‐diphosphate in healthy women
por: Burns, Rebecca N., et al.
Publicado: (2015)

Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder–Robinson syndrome
por: Stewart, Tracy Murray, et al.
Publicado: (2023)

Distribution Evaluation of Tenofovir in the Breast Milk of Mothers With HBeAg-Positive Chronic HBV Infection After Treatment With Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate by a Sensitive UPLC-MS/MS Method
por: Yang, Na, et al.
Publicado: (2021)

A Comparison of the Pharmacokinetics and Safety of Dapagliflozin Formate, an Ester Prodrug of Dapagliflozin, to Dapagliflozin Propanediol Monohydrate in Healthy Subjects
por: Kim, Hyun Chul, et al.
Publicado: (2023)

Population pharmacokinetics of tenofovir given as either tenofovir disoproxil fumarate or tenofovir alafenamide in an African population
por: Kawuma, Aida N., et al.
Publicado: (2023)

3-year Treatment of Tenofovir Alafenamide vs. Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China
por: Hou, Jinlin, et al.
Publicado: (2021)

Suppression of HBV by Tenofovir in HBV/HIV Coinfected Patients: A Systematic Review and Meta-Analysis
por: Price, Huw, et al.
Publicado: (2013)

Understanding the pharmacokinetics of prodrug and metabolite
por: Cho, Seungil, et al.
Publicado: (2018)

Renal safety of tenofovir and/or entecavir in patients with chronic HBV monoinfection
por: Yang, Young-Mo, et al.
Publicado: (2017)

Effectiveness of tenofovir or telbivudine in preventing HBV vertical transmission for pregnancy
por: Zeng, Jianyong, et al.
Publicado: (2019)

Pharmacokinetic/Pharmacodynamic Determination and Preclinical Pharmacokinetics of the β-Lactamase Inhibitor ETX1317 and Its Orally Available Prodrug ETX0282
por: O’Donnell, John, et al.
Publicado: (2020)

Force to Rebalance Control of HRG and Suppression of Its Errors on the Basis of FPGA
por: Wang, Xu, et al.
Publicado: (2011)

Sidekick dynamically rebalances contractile and protrusive forces to control tissue morphogenesis
por: Malin, Jacob, et al.
Publicado: (2022)

Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity
por: Stachulski, Andrew V., et al.
Publicado: (2023)

Vaginal microbiota and mucosal pharmacokinetics of tenofovir in healthy women using tenofovir and tenofovir/levonorgestrel vaginal rings
por: Thurman, Andrea Ries, et al.
Publicado: (2019)

Clinical and Preclinical Single-Dose Pharmacokinetics of VIR-2218, an RNAi Therapeutic Targeting HBV Infection
por: Gupta, Sneha V., et al.
Publicado: (2021)

Antiviral kinetics of tenofovir alafenamide and tenofovir disoproxil fumarate over 24 weeks in women of childbearing potential with chronic HBV
por: Pan, Calvin Q., et al.
Publicado: (2021)

Anti-Inflammatory and Anticoagulant Activities of Synthesized NSAID Prodrug Esters
por: Abualhasan, Murad N., et al.
Publicado: (2020)

Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes
por: Lee, Ah Ram, et al.
Publicado: (2021)

Comparative pharmacokinetics between tenofovir disoproxil phosphate and tenofovir disoproxil fumarate in healthy subjects
por: Lee, Sangmi, et al.
Publicado: (2021)

First-In-Human Study on Pharmacokinetics, Safety, and Tolerability of Single and Multiple Escalating Doses of Hepenofovir, a Novel Hepatic Targeting Prodrug of Tenofovir in Healthy Chinese Subjects
por: Zhang, Hong, et al.
Publicado: (2022)

Antidepressant Effects of Rosemary Extracts Associate With Anti-inflammatory Effect and Rebalance of Gut Microbiota
por: Guo, Ying, et al.
Publicado: (2018)

Barbaloin Treatment Contributes to the Rebalance of Glucose and Lipid Homeostasis of Gestational Diabetes Mellitus Mice
por: Wang, Yong, et al.
Publicado: (2020)

Rebalance of the Polyamine Metabolism Suppresses Oxidative Stress and Delays Senescence in Nucleus Pulposus Cells
por: Che, Hui, et al.
Publicado: (2022)

An ultralong-acting tenofovir ProTide nanoformulation achieves monthslong HBV suppression
por: Das, Srijanee, et al.
Publicado: (2022)

Tenofovir vs Entecavir Among Patients With HBV-Related HCC After Resection
por: Li, Pengpeng, et al.
Publicado: (2023)

RNA Interference Can Rebalance the Nitrogen Sink of Maize Seeds without Losing Hard Endosperm
por: Wu, Yongrui, et al.
Publicado: (2012)

Microcirculatory response to fluid challenge: should we prefer balanced colloids to rebalance tissue perfusion?
por: Donati, A, et al.
Publicado: (2013)

Combined Extracts of Herba Epimedii and Fructus Ligustri Lucidi Rebalance Bone Remodeling in Ovariectomized Rats
por: Chen, Yuheng, et al.
Publicado: (2019)

Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin
por: Leignadier, Julie, et al.
Publicado: (2023)

Pharmacokinetics of Tenofovir Alafenamide Fumarate and Tenofovir in the Chinese People: Effects of Non-Genetic Factors and Genetic Variations
por: Li, Xue, et al.
Publicado: (2021)

1591 Hepatitis B outcome in coinfected HIV-HBV individuals in the tenofovir/emtricitabine era
por: Nguyen, Divien, et al.
Publicado: (2014)

Synthesis, In Vitro and In Vivo Evaluation of the N-ethoxycarbonylmorpholine Ester of Diclofenac as a Prodrug
por: Jilani, Jamal A., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fik1e5p2flsvb7o6ihj5i77bb8