Discovering monoacylglycerol lipase inhibitors by a combination of fluorogenic substrate assay and activity-based protein profiling

The endocannabinoid 2-arachidonoylglycerol (2-AG) is predominantly metabolized by monoacylglycerol lipase (MAGL) in the brain. Selective inhibitors of MAGL provide valuable insights into the role of 2-AG in a variety of (patho)physiological processes and are potential therapeutics for the treatment...

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Detalles Bibliográficos
Autores principales: Deng, Hui, Zhang, Qianwen, Lei, Qian, Yang, Na, Yang, Kai, Jiang, Jianbing, Yu, Zhiyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465256/
https://www.ncbi.nlm.nih.gov/pubmed/36105202
http://dx.doi.org/10.3389/fphar.2022.941522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465256/
https://www.ncbi.nlm.nih.gov/pubmed/36105202
http://dx.doi.org/10.3389/fphar.2022.941522

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