RNA-sequencing and mass-spectrometry proteomic time-series analysis of T-cell differentiation identified multiple splice variants models that predicted validated protein biomarkers in inflammatory diseases

Profiling of mRNA expression is an important method to identify biomarkers but complicated by limited correlations between mRNA expression and protein abundance. We hypothesised that these correlations could be improved by mathematical models based on measuring splice variants and time delay in prot...

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Detalles Bibliográficos
Autores principales: Magnusson, Rasmus, Rundquist, Olof, Kim, Min Jung, Hellberg, Sandra, Na, Chan Hyun, Benson, Mikael, Gomez-Cabrero, David, Kockum, Ingrid, Tegnér, Jesper N., Piehl, Fredrik, Jagodic, Maja, Mellergård, Johan, Altafini, Claudio, Ernerudh, Jan, Jenmalm, Maria C., Nestor, Colm E., Kim, Min-Sik, Gustafsson, Mika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465313/
https://www.ncbi.nlm.nih.gov/pubmed/36106020
http://dx.doi.org/10.3389/fmolb.2022.916128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465313/
https://www.ncbi.nlm.nih.gov/pubmed/36106020
http://dx.doi.org/10.3389/fmolb.2022.916128

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