Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP(3)-evoked changes in sino-atrial node beat rate

Atrial arrhythmias, such as atrial fibrillation (AF), are a major mortality risk and a leading cause of stroke. The IP(3) signalling pathway has been proposed as an atrial-specific target for AF therapy, and atrial IP(3) signalling has been linked to the activation of calcium sensitive adenylyl cycl...

Descripción completa

Detalles Bibliográficos
Autores principales: Bose, Samuel J., Read, Matthew J., Akerman, Emily, Capel, Rebecca A., Ayagama, Thamali, Russell, Angela, Terrar, Derek A., Zaccolo, Manuela, Burton, Rebecca A. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465815/
https://www.ncbi.nlm.nih.gov/pubmed/36105228
http://dx.doi.org/10.3389/fphar.2022.951897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465815/
https://www.ncbi.nlm.nih.gov/pubmed/36105228
http://dx.doi.org/10.3389/fphar.2022.951897

Ejemplares similares