Cargando…

Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP(3)-evoked changes in sino-atrial node beat rate

Atrial arrhythmias, such as atrial fibrillation (AF), are a major mortality risk and a leading cause of stroke. The IP(3) signalling pathway has been proposed as an atrial-specific target for AF therapy, and atrial IP(3) signalling has been linked to the activation of calcium sensitive adenylyl cycl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bose, Samuel J., Read, Matthew J., Akerman, Emily, Capel, Rebecca A., Ayagama, Thamali, Russell, Angela, Terrar, Derek A., Zaccolo, Manuela, Burton, Rebecca A. B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465815/ https://www.ncbi.nlm.nih.gov/pubmed/36105228 http://dx.doi.org/10.3389/fphar.2022.951897

Ejemplares similares

IP(3)-mediated Ca(2+) release regulates atrial Ca(2+) transients and pacemaker function by stimulation of adenylyl cyclases
por: Capel, Rebecca A., et al.
Publicado: (2021)

Emerging Evidence for cAMP-calcium Cross Talk in Heart Atrial Nanodomains Where IP(3)-Evoked Calcium Release Stimulates Adenylyl Cyclases
por: Burton, Rebecca-Ann B., et al.
Publicado: (2021)

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex
por: Tarnawski, Laura, et al.
Publicado: (2018)

On-demand male contraception via acute inhibition of soluble adenylyl cyclase
por: Balbach, Melanie, et al.
Publicado: (2023)

Role of Adenylyl Cyclase Type 7 in Functions of BV-2 Microglia
por: Hu, Yawen, et al.
Publicado: (2022)

New Perspectives on Plant Adenylyl Cyclases
por: Ruzvidzo, Oziniel, et al.
Publicado: (2019)

Expression and functions of adenylyl cyclases in the CNS
por: Devasani, Karan, et al.
Publicado: (2022)

Function of Adenylyl Cyclase in Heart: the AKAP Connection
por: Baldwin, Tanya A., et al.
Publicado: (2018)

A modified density gradient proteomic-based method to analyze endolysosomal proteins in cardiac tissue
por: Ayagama, Thamali, et al.
Publicado: (2021)

Soluble Adenylyl Cyclase Is Localized to Cilia and Contributes to Ciliary Beat Frequency Regulation via Production of cAMP
por: Schmid, Andreas, et al.
Publicado: (2007)

Structural basis of adenylyl cyclase 9 activation
por: Qi, Chao, et al.
Publicado: (2022)

Soluble adenylyl cyclase is essential for proper lysosomal acidification
por: Rahman, Nawreen, et al.
Publicado: (2016)

Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6
por: Bull Melsom, Caroline, et al.
Publicado: (2019)

Selective coupling of type 6 adenylyl cyclase with type 2 IP(3) receptors mediates direct sensitization of IP(3) receptors by cAMP
por: Tovey, Stephen C., et al.
Publicado: (2008)

Dominant regulation of interendothelial cell gap formation by calcium-inhibited type 6 adenylyl cyclase
por: Cioffi, Donna L., et al.
Publicado: (2002)

Specific inhibition of adenylyl-cyclase isoform 5 by mood stabilizers may be related to their mechanism of action
por: Mann, Liad, et al.
Publicado: (2010)

Allosteric Inhibition of Adenylyl Cyclase Type 5 by G-Protein: A Molecular Dynamics Study
por: Frezza, Elisa, et al.
Publicado: (2020)

Gα(i1) inhibition mechanism of ATP-bound adenylyl cyclase type 5
por: Narzi, Daniele, et al.
Publicado: (2021)

Selective inhibition of adenylyl cyclase subtype 1 reduces inflammatory pain in chicken of gouty arthritis
por: Liu, Ren-Hao, et al.
Publicado: (2021)

Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP(3)R2 circuit
por: Santana Nunez, Dianicha, et al.
Publicado: (2023)

Activation of adenylyl cyclase in Chlamydomonas reinhardtii by adhesion and by heat
Publicado: (1993)

Editorial: Adenylyl cyclase isoforms as potential drug targets
por: Brust, Tarsis F., et al.
Publicado: (2022)

Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection
por: Vatner, Stephen F., et al.
Publicado: (2015)

Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains
por: Ren, Lu, et al.
Publicado: (2022)

Exploring the inhibition mechanism of adenylyl cyclase type 5 by n-terminal myristoylated Gα(i1)
por: van Keulen, Siri Camee, et al.
Publicado: (2017)

Adult Type 3 Adenylyl Cyclase–Deficient Mice Are Obese
por: Wang, Zhenshan, et al.
Publicado: (2009)

Spatial resolution of cAMP signaling by soluble adenylyl cyclase
por: Caldieri, Giusi, et al.
Publicado: (2016)

Prognosis and regulation of an adenylyl cyclase network in acute myeloid leukemia
por: Chen, Si-Liang, et al.
Publicado: (2020)

The evolutionary conservation of eukaryotic membrane-bound adenylyl cyclase isoforms
por: Schultz, Joachim E.
Publicado: (2022)

Gα(s), adenylyl cyclase, and their relationship to the diagnosis and treatment of depression
por: Schappi, Jeffrey M., et al.
Publicado: (2022)

Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin
por: Bhatia, Vikram, et al.
Publicado: (2023)

Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ
por: Yen, Yu-Chen, et al.
Publicado: (2023)

Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide
por: Townsend, Philip D., et al.
Publicado: (2009)

G protein-regulated endocytic trafficking of adenylyl cyclase type 9
por: Lazar, André M, et al.
Publicado: (2020)

Role of an adenylyl cyclase isoform in ethanol's effect on cAMP regulated gene expression in NIH 3T3 cells
por: Hill, Rebecca A., et al.
Publicado: (2016)

Cytosolic calcium ions exert a major influence on the firing rate and maintenance of pacemaker activity in guinea-pig sinus node
por: Capel, Rebecca A., et al.
Publicado: (2015)

The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeat
por: Capel, Rebecca A., et al.
Publicado: (2015)

Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures
por: Cohen, Joseph R, et al.
Publicado: (2010)

Role of adenylyl cyclase in reduced β-adrenoceptor-mediated vasorelaxation during maturation
por: López-Canales, O.A., et al.
Publicado: (2016)

AmOctα2R: Functional Characterization of a Honeybee Octopamine Receptor Inhibiting Adenylyl Cyclase Activity
por: Blenau, Wolfgang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7b9cbhspi3p307if495s66nnnf