Turning the Other Cheek: Influence of the cis-Tetrafluorocyclohexyl Motif on Physicochemical and Metabolic Properties

[Image: see text] The targeted introduction of substituents in order to tailor a molecule’s pharmacologic, physicochemical, and metabolic properties has long been of interest to medicinal chemists. The all-cis tetrafluorocyclohexyl motif—dubbed Janus face, due to its electrostatically polarized cycl...

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Detalles Bibliográficos
Autores principales: Wang, Yong, Lee, Wendy, Chen, Yi-Chen, Zhou, Yuhui, Plise, Emile, Migliozzi, Madyson, Crawford, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465827/
https://www.ncbi.nlm.nih.gov/pubmed/36105337
http://dx.doi.org/10.1021/acsmedchemlett.2c00312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465827/
https://www.ncbi.nlm.nih.gov/pubmed/36105337
http://dx.doi.org/10.1021/acsmedchemlett.2c00312

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