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Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination
BACKGROUND: This clinical trial evaluated a novel telomerase-targeting therapeutic cancer vaccine, UV1, in combination with ipilimumab, in patients with metastatic melanoma. Translational research was conducted on patient-derived blood and tissue samples with the goal of elucidating the effects of t...
Autores principales: | Ellingsen, Espen Basmo, Bounova, Gergana, Kerzeli, Iliana, Anzar, Irantzu, Simnica, Donjete, Aamdal, Elin, Guren, Tormod, Clancy, Trevor, Mezheyeuski, Artur, Inderberg, Else Marit, Mangsbo, Sara M., Binder, Mascha, Hovig, Eivind, Gaudernack, Gustav |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465869/ https://www.ncbi.nlm.nih.gov/pubmed/36089578 http://dx.doi.org/10.1186/s12967-022-03624-z |
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