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Fragment Ligands of the m(6)A-RNA Reader YTHDF2
[Image: see text] We report 17 small-molecule ligands that compete with N6-methyladenosine (m(6)A) for binding to the m(6)A-reader domain of YTHDF2 (YT521-B homology domain family 2). We determined their binding mode at high resolution by X-ray crystallography and quantified their affinity by a fluo...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9466600/ https://www.ncbi.nlm.nih.gov/pubmed/36110386 http://dx.doi.org/10.1021/acsmedchemlett.2c00303 |