Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies

New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the highest anti-proliferative activities with IC(50) values of 15.4 and 9.8 µM against HCT-116 and HepG2, respectively compared to sorafenib (I...

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Detalles Bibliográficos
Autores principales: Yousef, Reda G., Elwan, Alaa, Gobaara, Ibraheem M. M., Mehany, Ahmed B. M., Eldehna, Wagdy M., El-Metwally, Souad A., A. Alsfouk, Bshra, Elkaeed, Eslam B., Metwaly, Ahmed M., Eissa, Ibrahim H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9466619/
https://www.ncbi.nlm.nih.gov/pubmed/35980113
http://dx.doi.org/10.1080/14756366.2022.2110868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9466619/
https://www.ncbi.nlm.nih.gov/pubmed/35980113
http://dx.doi.org/10.1080/14756366.2022.2110868

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