Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFR(WT) and EGFR(T790M)

New 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesised to act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives were assessed for their in vitro anti-proliferative activities against A549 and HCT-116 cancer cells. Compounds 8, 10, 12a, and 12b s...

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Detalles Bibliográficos
Autores principales: Gaber, Ahmed A., Sobhy, Mohamed, Turky, Abdallah, Abdulwahab, Hanan Gaber, Al-Karmalawy, Ahmed A., Elhendawy, Mostafa. A., Radwan, Mohamed. M., Elkaeed, Eslam B., Ibrahim, Ibrahim M., Elzahabi, Heba S. A., Eissa, Ibrahim H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9466626/
https://www.ncbi.nlm.nih.gov/pubmed/36000168
http://dx.doi.org/10.1080/14756366.2022.2112575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9466626/
https://www.ncbi.nlm.nih.gov/pubmed/36000168
http://dx.doi.org/10.1080/14756366.2022.2112575

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