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P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy
P-glycoprotein (P-gp) is expressed on brain microvessel endothelial cells of blood-brain barrier (BBB) and elevated after cerebral ischemia. In this study, we explored the influence and potential mechanisms of P-gp on BBB function in experimental ischemic stroke in vivo and in vitro. Middle cerebral...
Autores principales: | Huang, Liangliang, Chen, Yan, Liu, Rui, Li, Binbin, Fei, Xuan, Li, Xiang, Liu, Ge, Li, Yunman, Xu, Baohui, Fang, Weirong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9466967/ https://www.ncbi.nlm.nih.gov/pubmed/36186136 http://dx.doi.org/10.14336/AD.2022.0225 |
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